Syntheses of 2-n-alkylisothio-5-fluoro-4(1 or 3H)-pyrimidinone derivatives.
نویسندگان
چکیده
منابع مشابه
6-Ethyl-5-fluoro-2-methoxypyrimidin-4(3H)-one
In the title compound, C(7)H(9)FN(2)O(2), the meth-oxy and ethyl groups form dihedral angles of 1.4 (2) and 73.5 (3)°, respectively, with the mean plane of the pyrimidine ring. In the crystal structure, two mol-ecules are linked by a pair of N-H⋯O hydrogen bonds, forming a centrosymmetric dimer.
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The title compound, C(15)H(11)FN(4)OS, crystallizes with three independent mol-ecules (A, B and C) in the asymmetric unit. The dihedral angles between the nine-membered 5-fluoro-indolin-2-one ring system and the benzene ring are 22.14 (11), 12.56 (11) and 3.70 (11)° in mol-ecules A, B and C, respectively. In all three mol-ecules, intra-molecular cyclic N-H⋯O and C-H⋯S hydrogen-bonding inter-act...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1985
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.33.5053